Monthly Archives: June 2016

Best medicine tips for migraines

A wide variety of pharmacological interventions such as opiates, benzodiazepines, and prophylactic medications have been described that offer partial relief to migraine sufferers. Reviews have also described a variety of empirically supported non-pharmacological approaches to preventing or stopping headaches.

Recent randomized controlled trials have demonstrated the efficacy of meditation-based interventions as a treatment for headache pain. Though spiritual meditation has been found to reduce the frequency of migraines and physiological reactivity to stress, little is known about how introducing a spirituality component into a meditation intervention impacts use of analgesic medicine. The results from the study support previous research suggesting that spiritual meditation may be more effective for pain tolerance and migraine coping than non-spiritual meditation alternatives.

In this study, 92 meditation-naïve participants with frequent migraines (>2 per month) were randomly assigned to one of four groups that used a meditation phrase or technique: (1) Spiritual Meditation (exp. “God is love”), (2) Internally Focused Secular Meditation (exp. “I am content”), (3) Externally Focused Secular Meditation (exp. “Sand is soft,”), or (4) Progressive Muscle Relaxation (technique). Then, the participants practiced their assigned meditation technique for 20 minutes per day over 30 days while completing daily headache diaries. Headache frequency, headache severity, and pain medication use were recorded and assessed. Migraine frequency decreased significantly in the Spiritual Meditation group compared to other groups. Headache severity ratings did not differ across groups. All four groups showed decreased analgesic medication use over time — however, medication usage for migraine headaches had a sharper decline in the Spiritual Meditation group compared to other groups.

The advantage of fruit to avoid canser

They discovered this by examining a common household pest  the fruit fly.

“Flies and humans have a lot in common in terms of genes and pathways for developing cancer,” said Wu Min Deng, professor of biological science at Florida State and the senior author on the paper.

Deng and his now former postdoctoral researcher Yoichiro Tamori found that in the fruit fly, tumors always originated from specific regions of the epithelial tissue.

Their findings are laid out in a study published in PLOS Biology.

Deng and Tamori were interested in examining basic pathways and tissue structures where tumors might form. Many scientists study the development in fruit flies as a model to determine the basic fundamentals of several diseases, including cancer.

“At its heart, this is basic research investigating how cancer gets started,” Deng said. “What are the tissue microenvironments that facilitate tumor formation?”

In examining fruit flies, researchers looked at the developing epithelial tissues in fruit fly larvae, called imaginal discs. The discs eventually form an outer layer structure of an adult fly. These discs are formed by sheets of cells called epithelia which have distinct upper and lower sides.

In mammals, similarly, epithelia cover all surfaces and line all cavities of the body. More than 80 percent of human cancers are originated from epithelial tissues.

Deng and his team used genetic engineering to turn off tumor suppressor genes in the larvae that are also found in humans and other animals. After they inactivated the tumor suppressor gene, the researchers discovered that tumors always originate from a specific area of the disc.

These tumor hotspots all involved an oncogenic signaling pathway that has been shown to be involved in many types of human cancers. Signaling pathways are essentially the communication networks within a cell telling it to perform a specific function.

Researchers found that on the basa or underside of the epithelial sheets, the tumor hotspot had a unique and rigid structure. Because of this robust structure at the basal side, pro tumor cells pop out of the apical side or top of the sheet — of the epithelia and start tumor formation.

But in other areas of the epithelial tissue what researchers called a tumor cold spot — the basal side of the tissue was more loosely constructed and pro-tumor cells were extruded from the basal side and die.

Deng said he and Tamori hope to continue their work looking at cancer and delve deeper into the signaling pathways and tissues in mammal systems